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AZ194

CAS No. 2241651-99-8

AZ194( CRMP2-Ubc9-NaV1.7 inhibitor 194 )

Catalog No. M28702 CAS No. 2241651-99-8

CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 188 In Stock
5MG 169 In Stock
10MG 275 In Stock
25MG 511 In Stock
50MG 724 In Stock
100MG 1014 In Stock
200MG Get Quote In Stock
500MG 2027 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AZ194
  • Note
    Research use only, not for human use.
  • Brief Description
    CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
  • Description
    CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.
  • In Vitro
    ——
  • In Vivo
    AZ194 would provide pain relief in rat models of chemotherapy- and nerve injury- induced neuropathic pain. AZ194 (orally; at 2 and 10 mg/kg) restores mechanical sensitivity in animals with chemotherapy-induced and nerve injury-induced neuropathic nociception.AZ194 (10 mg/kg; ip; CD1 male mice) does not affect motor performance (open field). AZ194 synergizes with commonly used painkillers, engages NaV1.7-dependent endogenous opioid signaling.
  • Synonyms
    CRMP2-Ubc9-NaV1.7 inhibitor 194
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241651-99-8
  • Formula Weight
    567.637
  • Molecular Formula
    C34H31F2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (58.72 mM)
  • SMILES
    COc1cc(ccc1OCc1cccc(F)c1)C(=O)N1CCC(CC1)c1nc2ccccc2n1Cc1cccc(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dzierba CD, Hartz RA, Bronson JJ. Recent advances in corticotropin-releasing factor receptor antagonists. Annu Rep Med Chem. 2008;43:3–23.
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