Cart
sales@molnova.com
Mesdopetam hemitartrate
CAS No. 2562346-14-7
Mesdopetam hemitartrate( 1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1) | IRL790 hemitartrate )
Catalog No. M28670 CAS No. 2562346-14-7
Mesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 76 | In Stock |
|
| 10MG | 107 | In Stock |
|
| 25MG | 188 | In Stock |
|
| 50MG | 305 | In Stock |
|
| 100MG | 500 | In Stock |
|
| 200MG | 712 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameMesdopetam hemitartrate
-
NoteResearch use only, not for human use.
-
Brief DescriptionMesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor).
-
DescriptionMesdopetam hemitartrate is an antagonist of dopamine D3 receptor (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor). It has psychomotor stabilizing properties.
-
In Vitro——
-
In VivoMesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80. Animal Model:Male Sprague-Dawley ratsDosage:3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl) Administration:s.c. was administered subcutaneously 4 min before the start of recording Result:Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.
-
Synonyms1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1) | IRL790 hemitartrate
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
Recptorp38α
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2562346-14-7
-
Formula Weight700.77
-
Molecular FormulaC28H42F2N2O12S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?H2O : 100 mg/mL (142.70 mM)
-
SMILESCCCNCCOC1=CC(S(=O)(C)=O)=CC(F)=C1.CCCNCCOC2=CC(S(=O)(C)=O)=CC(F)=C2.O=C(O)[C@H](O)[C@@H](O)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Baker W, et al. Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (aistm's) and β-agonists for the treatment of pulmonary inflammation and bronchoconstriction. WO 2008076265 A1.
molnova catalog
related products
-
Perphenazine dihydro...
Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist that acts on D2 (Ki: 0.56 nM), D3 (Ki: 0.43 nM), and 5-HT2A (Ki: 0.6 nM) receptors, and also binds Alpha-1A adrenergic receptors.
-
D4R agonist-1
D4R agonist-1 is a selective and potent D4R partial agonist (Ki:2.2 nM).D4R agonist-1 can be used to study neurological diseases.
-
Talipexole dihydroch...
Talipexole dihydrochloride is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.
