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N-piperidine Ibrutinib
CAS No. 330785-90-5
N-piperidine Ibrutinib( —— )
Catalog No. M28669 CAS No. 330785-90-5
N-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 302 | Get Quote |
|
| 10MG | 444 | Get Quote |
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| 25MG | 711 | Get Quote |
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| 50MG | 1008 | Get Quote |
|
| 100MG | 1341 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameN-piperidine Ibrutinib
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NoteResearch use only, not for human use.
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Brief DescriptionN-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively.
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DescriptionN-piperidine Ibrutinib is a potent BTK inhibitor with IC50s of 51.0 for WT BTK and 30.7 nM for C481S BTK respectively. N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.(In Vitro):N-piperidine Ibrutinib can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC50s of 374, 162, and 8.3 nM, respectively.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBTK
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number330785-90-5
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Formula Weight386.45
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Molecular FormulaC22H22N6O
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Purity>98% (HPLC)
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Solubility——
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SMILESNc1c(c(-c(cc2)ccc2Oc2ccccc2)nn2C3CCNCC3)c2ncn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76.
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