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Thalidomide-PEG4-Propargyl
CAS No. 2098799-77-8
Thalidomide-PEG4-Propargyl( Thalidomide-O-PEG4-Propargyl )
Catalog No. M28653 CAS No. 2098799-77-8
Thalidomide-PEG4-Propargyl is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 63 | In Stock |
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| 10MG | 89 | In Stock |
|
| 25MG | 145 | In Stock |
|
| 50MG | 211 | In Stock |
|
| 100MG | 314 | In Stock |
|
| 200MG | 451 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameThalidomide-PEG4-Propargyl
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-PEG4-Propargyl is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology.
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DescriptionThalidomide-PEG4-Propargyl is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology.
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In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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In Vivo——
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SynonymsThalidomide-O-PEG4-Propargyl
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PathwayOthers
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TargetOther Targets
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Recptorestrogen receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2098799-77-8
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Formula Weight488.49
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Molecular FormulaC24H28N2O9
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Purity>98% (HPLC)
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Solubility——
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SMILESC#CCOCCOCCOCCOCCOc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gauthier S1,et al.Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution.J Enzyme Inhib Med Chem. 2005 Apr;20(2):165-77.
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