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VPC-18005
CAS No. 2242480-48-2
VPC-18005( —— )
Catalog No. M28514 CAS No. 2242480-48-2
VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 135 | In Stock |
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| 5MG | 98 | In Stock |
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| 10MG | 159 | In Stock |
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| 25MG | 265 | In Stock |
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| 50MG | 369 | In Stock |
|
| 100MG | 500 | In Stock |
|
| 200MG | 643 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameVPC-18005
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NoteResearch use only, not for human use.
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Brief DescriptionVPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.
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DescriptionVPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA.(In Vitro):VPC-18005 (1 and 10 μM) produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh. VPC-18005 (5 μM) inhibits pETS-luc reporter activity with IC50s of 3 and 6 μM in PNT1B-ERG and VCaP cells, respectively. VPC-18005 antagonizes the metastatic potential of ERG-expressing prostate cells and suppresses ERG reporter activity without exhibiting overt cytotoxicity. VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.
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In VitroVPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively.VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity.VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro.VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells.The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh. Cell Viability AssayCell Line:PNT1B-Mock cells and PNT1B-ERG cells.Concentration:5 μM.Incubation Time:24 h.Result:Inhibited migration and invasion of prostate cell lines in vitro.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2242480-48-2
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Formula Weight319.38
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Molecular FormulaC15H17N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (195.69 mM)
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SMILESN(/N=C\C1=CC=C(C(C)C)C=C1)=C\2/SC(CC(O)=O)C(=O)N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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