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SRI-37330
CAS No. 2322245-42-9
SRI-37330( —— )
Catalog No. M28482 CAS No. 2322245-42-9
SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 353 | In Stock |
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| 50MG | 600 | In Stock |
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| 100MG | 889 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSRI-37330
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NoteResearch use only, not for human use.
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Brief DescriptionSRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis.
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DescriptionSRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis.
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In VitroSRI-37330 (1 μM, 24 h) inhibits the activity of the human TXNIP promoter in INS-1 cells.SRI-37330 (1 μM, 24 h) inhibits Mrna and protein levels of TXNIP in INS-1 cells.SRI-37330 (5 μM, 24 h) inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter.SRI-37330 (5 μM, 24 h) lowers glucagon secretion in TC1-6 cells.SRI-37330 (0-5 μM, 24 h) inhibits glucagon-induced glucose output from primary hepatocytes.RT-PCR Cell Line:INS-1 cells Concentration:1 μM Incubation Time:24 h Result:Inhibited endogenous TXNIP mRNA expression with an IC50 of 0.64 μM.
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In VivoSRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) decreases glucagon secretion and action and blocks hepatic glucose output.SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) is well tolerated in male C57BL/6J mice.SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) reverses obesity- and STZ-induced diabetes and hepatic steatosis in mice. Animal Model:C57BL/6J mice Dosage:100 mg/kg Administration:Oral administration (p.o.), in drinking water, 3 weeks.Result:Lowered serum glucagon levels, inhibited hepatic glucose production and improved glucose homeostasis in mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorCK2
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Research Area——
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Indication——
Chemical Information
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CAS Number2322245-42-9
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Formula Weight388.41
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Molecular FormulaC16H19F3N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (257.46 mM)
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Jacoline
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