Manganese(salen) chloride

Research use only, not for human use.

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.(In Vitro):Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation. (In Vivo):Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.

Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage:25 mg/kg/day Administration:I.p. 3 times a week for 4 weeksResult:Prevented myocardial oxidant damage provoked by biomechanical stress.Improved survival following biomechanical stress.Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.

EUK-8

Others

Other Targets

monophenolase

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53177-12-1

356.69

C16H14ClMnN2O2

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (23.35 mM)

[Cl-].[Mn+5].[O-]c1ccccc1\C=[N-]\CC\[N-]=C/c1ccccc1[O-]

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(-20℃)

With Ice Pack

≥ 2 years