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ErSO
CAS No. 2407860-35-7
ErSO( —— )
Catalog No. M28247 CAS No. 2407860-35-7
ErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 181 | In Stock |
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| 5MG | 164 | In Stock |
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| 10MG | 263 | In Stock |
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| 25MG | 434 | In Stock |
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| 50MG | 597 | In Stock |
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| 100MG | 798 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameErSO
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NoteResearch use only, not for human use.
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Brief DescriptionErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.
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DescriptionErSO is a selective activator of anticipatory unfolded protein response (UPR) via ERα receptor. ErSO can be used in studies about anti-cancer.(In Vitro):In MCF-7 cells, ErSO (1-1000 nM) inhibits cell viability with an IC50 of 20.3 nM. ErSO (1 μM) rapidly kills ERα-positive breast cancer cells in TYS and TDG cells and induces rapid killing of ERα-positive MCF-7 human breast cancer cells.(In Vivo):ErSO (10 and 40 mg/kg; p.o.) induces >100000-fold regression (to undetectable amounts) within 14 days and >10000-fold regression of TYS-luciferase-expressing breast tumors in all five mice. In Nu/J mice, ErSO (10 or 40 mg/kg; p.o.) eliminates tumors with >90% reduction in all cases.
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In VitroCell Viability Assay Cell Line:MCF-7 cells Concentration:1~1000 nM Incubation Time:24 hours Result: Showed that IC50 value is 20.3 nM in MCF-7 cells and inhibited cell viability.
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In VivoAnimal Model:Nu/J mice Dosage:10 or 40 mg/kg Administration:P.o.; 21 days Result:Resulted in elimination of these tumors, with >90% reduction in all cases.Animal Model:Mice Dosage:0.5~40 mg/kg Administration:P.o.; 3 weeks Result:Sufficient for a robust response.Animal Model:Mice Dosage:40 mg/kg Administration:I.p.; 14 days Result:Metastatic burden was greatly reduced
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorγ secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number2407860-35-7
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Formula Weight453.33
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Molecular FormulaC22H13F6NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 120 mg/mL (264.71 mM)
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SMILESO=C1[C@@](C=2C(N1)=C(C(F)(F)F)C=CC2)(C3=CC=C(OC(F)(F)F)C=C3)C4=CC=C(O)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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RES-701-1
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24-Norursodeoxycholi...
24-norursodeoxycholic acid is a side chain-shortened C23 homolog of UDCA.It has shown potent anti-inflammatory, anti-cholestatic, and anti-fibrotic properties.It is a Ursodeoxycholic Acid derivative. It is superior to Ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice24-norUrsodeoxycholic acid markedly improved liver tests and liver histology and significantly reduced hydroxyproline content and the number of infiltrating neutrophils and proliferating hepatocytes and cholangiocytes.?
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α-Synuclein (71-82) ...
α-Synuclein (71-82) (human) is the 71-82 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly abundant in presynaptic nerve terminals. α-Synuclein is a biomarker for Parkinson's disease (PD).
