Cart
sales@molnova.com
Desmorpholinyl Navitoclax-NH-Me
CAS No. 2365172-82-1
Desmorpholinyl Navitoclax-NH-Me( Desmorpholinyl ABT-263-NH-Me )
Catalog No. M28241 CAS No. 2365172-82-1
Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 173 | In Stock |
|
| 5MG | 107 | In Stock |
|
| 10MG | 171 | In Stock |
|
| 25MG | 314 | In Stock |
|
| 50MG | 414 | In Stock |
|
| 100MG | 539 | In Stock |
|
| 200MG | 710 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDesmorpholinyl Navitoclax-NH-Me
-
NoteResearch use only, not for human use.
-
Brief DescriptionDesmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .
-
DescriptionDesmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 .
-
In Vitro——
-
In Vivo——
-
SynonymsDesmorpholinyl ABT-263-NH-Me
-
PathwayAngiogenesis
-
TargetBcl-2
-
RecptorAChR|BACE1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2365172-82-1
-
Formula Weight918.55
-
Molecular FormulaC44H51ClF3N5O5S3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (108.87 mM)
-
SMILESCC(C)(CC1)CC(CN(CC2)CCN2c(cc2)ccc2C(NS(c(cc2)cc(S(C(F)(F)F)(=O)=O)c2N[C@H](CCNC)CSc2ccccc2)(=O)=O)=O)=C1c(cc1)ccc1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shrestha S, et al. Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia. Molecules. 2017 Dec 28;23(1):69.
molnova catalog
related products
-
Lisaftoclax
Bcl-2/Bcl-xl inhibitor 1 is a dual Bcl-2 and Bcl-xl inhibitor (IC50s: 2 nM and 5.9 nM for Bcl-2 and Bcl-xl) with anti-tumor activity. It is extracted from patent WO2018027097A1.
-
A09-003
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.
-
BCL6 inhibitor 14
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.
