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Propargylcholine

CAS No. 111755-76-1

Propargylcholine( Propargylcholine (bromide) )

Catalog No. M28160 CAS No. 111755-76-1

Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Propargylcholine
  • Note
    Research use only, not for human use.
  • Brief Description
    Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
  • Description
    Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
  • In Vitro
    Propargylcholine bromide (10, 50 μM; 24 h) incorporates into NIH 3T3 cells and shows strong staining in a concentration-dependent manner (fixed and stained with Alexa568-azide). Immunofluorescence Cell Line:NIH 3T3 cells Concentration:10, 50 μM Incubation Time:24 h Result:Showed strong staining proportional in intensity to the concentration of added Propargylcholine bromide.
  • In Vivo
    Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectivelyincorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey.
  • Synonyms
    Propargylcholine (bromide)
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial|PGE2|COX-1|E. coli
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    111755-76-1
  • Formula Weight
    208.099
  • Molecular Formula
    C7H14BrNO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 125 mg/mL (600.67 mM)
  • SMILES
    [Br-].C[N+](C)(CCO)CC#C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487.
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