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Zopolrestat
CAS No. 110703-94-1
Zopolrestat( CP 73850 | CP73850 | CP-73850 | Zopolrestat | Zopolrestatum )
Catalog No. M28023 CAS No. 110703-94-1
Zopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 291 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameZopolrestat
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NoteResearch use only, not for human use.
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Brief DescriptionZopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).
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DescriptionZopolrestat is a potent inhibitor of aldose reductase (IC50 = 3.1 nM).(In Vitro):Zopolrestat is a potent inhibitor of the enzymatic reduction of glyceraldehyde and glucose.(In Vivo):After the administration of Zopolrestat (2.5 mg/kg-50 mg/kg; p.o), the ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (made diabetic by iv injection of streptozotocin). Dosage:2.5 mg/kg-50 mg/kg Administration:P.o.; once-a-day for 5 days Result:Its ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.
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SynonymsCP 73850 | CP73850 | CP-73850 | Zopolrestat | Zopolrestatum
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PathwayEndocrinology/Hormones
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TargetReductase
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Recptorgastrin
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Research Area——
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Indication——
Chemical Information
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CAS Number110703-94-1
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Formula Weight419.38
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Molecular FormulaC19H12F3N3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (238.45 mM)
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SMILESOC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Szabadkai Istvan, et al. Novel Thiazolidinone Derivatives, Pharmaceutical Compositions Containing Them And Process For Preparing Same. WO1991008203A1
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