Gamma-Methylleucine

CAS No. 57224-50-7

Gamma-Methylleucine( gamma-Methyl-L-leucine | L-Neopentylglycine | 2-Amino-3-tert-butylpropionic acid )

Catalog No. M27985 CAS No. 57224-50-7

Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 27 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Gamma-Methylleucine
  • Note
    Research use only, not for human use.
  • Brief Description
    Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.
  • Description
    Gamma-Methylleucine is an auxiliary for copper-catalyzed asymmetric Michael reactions.(In Vivo):gamma-Methylleucine improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice . Gamma-methylleucine resulted in loss of or significantly decreased the biological activity of ET-1, while high affinity for the ETA (IC50 = 0.42-0.70 nM) and ETB (IC50 = 0.17-0.43 nM) receptor was retained . Gamma-methylleucine was shown to have high antagonist activitiesin Sarafotoxin S6c-induced vasoconstriction of rabbit pulmonary artery (ET-1: pA2 8.4) and have the desirable characteristic of possessing no agonist activity at either receptor subtype .
  • In Vitro
    Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
  • In Vivo
    ——
  • Synonyms
    gamma-Methyl-L-leucine | L-Neopentylglycine | 2-Amino-3-tert-butylpropionic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    57224-50-7
  • Formula Weight
    145.202
  • Molecular Formula
    C7H15NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 25 mg/mL (172.18 mM)
  • SMILES
    CC(C)(C)C[C@H](N)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50(12):160.
molnova catalog
related products
  • Sodium acetate

    Sodium acetate is Commonly used laboratory reagent.

  • 8-Hydroxygenistein

    8-Hydroxygenistein (8-OHG) is an antioxidant that can effectively scavenge nitric oxide (NO) and superoxide anion (O??). 8-Hydroxygenistein belongs to ortho-dihydroxy isoflavones (ODI) and is abundantly present in dark soy sauce and light soy sauce. Its antioxidant activity is stronger than that of its parent compound genistein. The content of 8-Hydroxygenistein is positively correlated with the antioxidant capacity of soy sauce (r = 0.959), and it remains highly stable even after being heated in boiling water for 60 minutes. During the brewing and storage of soy sauce, 8-Hydroxygenistein effectively prevents oxidative damage, making it promising for use in food antioxidant research.

  • RS domain derived pe...

    RS domain derived peptide