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BiP inducer X
CAS No. 101714-41-4
BiP inducer X( BIX )
Catalog No. M27965 CAS No. 101714-41-4
BiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 122 | In Stock |
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| 50MG | 206 | In Stock |
|
| 100MG | 346 | In Stock |
|
| 200MG | 511 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBiP inducer X
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NoteResearch use only, not for human use.
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Brief DescriptionBiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.
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DescriptionBiP inducer X is a selective inducer of immunoglobulin heavy chain binding protein (BiP)/GRP78 and an ER chaperone inducer. BiP inducer X prevents cell death in neurons and retinal cell lines.(In Vitro):Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.(In Vivo):In male adult ddY mice, BiP inducer X (20 μg) reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. BiP inducer X reduces the insults due to cerebral infarction.
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In VitroBiP inducer X (5?μM; 0-12 hours; SK-N-SH cells) increase BiP protein.The induction of BiP by BiP inducer X (BIX) is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway.BiP inducer X (5?μM; 12 hours; pretreatment with SK-N-SH cells) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4.
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In VivoBiP inducer X administration reduces the insults due to cerebral infarction.A 20?μg portion of BiP inducer X administration reduces ER stress-induced apoptosis induced in the penumbra by MCA occlusion. Animal Model:Male adult ddY mice weighing 24-34?g (Japan SLC)Dosage:20?μg (2?μl)Administration:Intracerebroventricularly Result:Significantly increased the level of BiP protein 24?h after administration, confirming that administration of BIX induces BiP protein in vivo.
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SynonymsBIX
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PathwayApoptosis
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TargetApoptosis
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RecptorNFAT5
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Research Area——
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Indication——
Chemical Information
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CAS Number101714-41-4
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Formula Weight209.22
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Molecular FormulaC9H7NO3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (238.98 mM)
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SMILESOc1ccc(cc1O)C(=O)CSC#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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NSC49652
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