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Home - Products - Cell Cycle/DNA Damage - AChR - VU0152099

VU0152099

CAS No. 612514-42-8

VU0152099( VU 0152099 | VU-0152099 )

Catalog No. M27937 CAS No. 612514-42-8

VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VU0152099
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
  • Description
    VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).
  • In Vitro
    VU0152099 (30 μM) induces a dose-dependent leftward shift of the acetylcholine (ACh) concentration response curve (CRC) with maximal shifts of 30-fold observed with 30 μM. VU0152099 dose-dependently potentiates the response to an EC20 concentration of ACh with EC50 values of 1.2 μM, and increases the maximal response to ACh to approximately 130%. VU0152099 is a potent positive allosteric modulator that enhance the response of the M4 receptor to the endogenous agonist ACh.
  • In Vivo
    VU0152099 (56.6 mg/kg; i.p.; once) reverses Amphetamine-induced hyperlocomotion in rats. Animal Model:Male Sprague-Dawley rats (270-300 g) injected with Amphetamine Dosage:56.6 mg/kg .Administration:i.p.; once Result:Reversed Amphetamine-induced hyperlocomotion in rats.
  • Synonyms
    VU 0152099 | VU-0152099
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    S1P
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    612514-42-8
  • Formula Weight
    355.41
  • Molecular Formula
    C18H17N3O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (35.17 mM)
  • SMILES
    Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc2OCOc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67.
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