Cart
sales@molnova.com
Home - Products - Others - Other Targets - PKUMDL-WQ-2101

PKUMDL-WQ-2101

CAS No. 304481-72-9

PKUMDL-WQ-2101( —— )

Catalog No. M27914 CAS No. 304481-72-9

PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
10MG 36 In Stock
25MG 79 In Stock
50MG 133 In Stock
100MG 231 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PKUMDL-WQ-2101
  • Note
    Research use only, not for human use.
  • Brief Description
    PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
  • Description
    PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
  • In Vitro
    Cell Viability Assay Cell Line:MDA-MB-468 cells Concentration:2.5 μM, 5.0 μM, 20 μM and 40 μM Incubation Time:24 hours Result:Caused cell cycle arrest.
  • In Vivo
    Animal Model:NOD.CB17 Scid/J mice injected with MDA-MB-468 cellsDosage:5 mg/kg, 10 mg/kg, 20 mg/kg Administration:i.p; daily; for 30 days Result:Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PDE9A|PDE5A1|PDE1B|PDE4D2|PDE10A1|PDE2A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    304481-72-9
  • Formula Weight
    317.26
  • Molecular Formula
    C14H11N3O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (394.01 mM)
  • SMILES
    O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)C2=CC=C(O)C=C2O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.1. Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88(5):836-845.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Polysorbate 20

    Polysorbate 20 (Tween-20) ,sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives, is used in the formulation of biotherapeutic products for both preventing surface adsorption and as a stabilizer against protein aggregation.

  • Ganirelix Acetate

    Ganirelix Acetate is a gonadotropin-releasing hormone (GnRH) receptor antagonist.

  • Blinin

    Blinin is a neoclerodane diterpene, isolated from the whole plant of Conyza blinii.

Sign In Join Free