Cart
sales@molnova.com
PKUMDL-WQ-2101
CAS No. 304481-72-9
PKUMDL-WQ-2101( —— )
Catalog No. M27914 CAS No. 304481-72-9
PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 36 | In Stock |
|
| 25MG | 79 | In Stock |
|
| 50MG | 133 | In Stock |
|
| 100MG | 231 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePKUMDL-WQ-2101
-
NoteResearch use only, not for human use.
-
Brief DescriptionPKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
-
DescriptionPKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with anti-tumor activity, it binds to site I.
-
In VitroCell Viability Assay Cell Line:MDA-MB-468 cells Concentration:2.5 μM, 5.0 μM, 20 μM and 40 μM Incubation Time:24 hours Result:Caused cell cycle arrest.
-
In VivoAnimal Model:NOD.CB17 Scid/J mice injected with MDA-MB-468 cellsDosage:5 mg/kg, 10 mg/kg, 20 mg/kg Administration:i.p; daily; for 30 days Result:Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorPDE9A|PDE5A1|PDE1B|PDE4D2|PDE10A1|PDE2A
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number304481-72-9
-
Formula Weight317.26
-
Molecular FormulaC14H11N3O6
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (394.01 mM)
-
SMILESO=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)C2=CC=C(O)C=C2O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.1. Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88(5):836-845.
molnova catalog
related products
-
Bisacodyl
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
-
β-Nicotinamide monon...
Nicotinamide ribotide (NMN) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway.
-
L-2-Phosphoglyceric ...
2-Phosphoglyceric acid (2PGA) is a glyceric acid which serves as the substrate in the ninth step of glycolysis. It is catalyzed by enolase into phosphoenolpyruvate (PEP) the penultimate step in the conversion of glucose to pyruvate.
