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Home - Products - JAK/STAT Signaling - Pim - K00135

K00135

CAS No. 869650-21-5

K00135( K-00135 | K 00135 | IMIDAZOPYRIDAZIN 1 | Imidazol[1,2-b]pyridazine 1 )

Catalog No. M27892 CAS No. 869650-21-5

K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 249 In Stock
2MG 167 In Stock
5MG 256 In Stock
10MG 375 In Stock
25MG 562 In Stock
100MG Get Quote In Stock
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Biological Information

  • Product Name
    K00135
  • Note
    Research use only, not for human use.
  • Brief Description
    K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
  • Description
    K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.(In Vitro):K00135 dose-dependently impairs the survival of murine Ba/F3 cells that have been rendered cytokine independent by overexpression of human PIMs. K00135 impairs survival and clonogenic growth of a panel of human acute leukemia cells. Exposure of K00135 significantly suppresses in vitro growth of leukemic blasts from five acute myelogenous leukemia patients but not of normal umbilical cord blood mononuclear cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    K-00135 | K 00135 | IMIDAZOPYRIDAZIN 1 | Imidazol[1,2-b]pyridazine 1
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    869650-21-5
  • Formula Weight
    306.36
  • Molecular Formula
    C18H18N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC=CC(=C1)C2=CN=C3C=CC(=NN32)NCC4CC4)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Honda S, Toyota T. Photo-triggered solvent-free metamorphosis of polymeric materials. Nat Commun. 2017 Sep 11;8(1):502.
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