HBF-0259

Research use only, not for human use.

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells.

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.

HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC50=1.5 μM) in HepDE19 cells, with an CC50 of >50 μM.HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells.

——

HBF 0259 | HBF0259

Immunology/Inflammation

Antiviral

HIV

——

——

957011-15-3

364.21

C16H12Cl2FN5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (274.57 mM)

Fc1cccc(Cl)c1C1CC(Nc2nnnn12)c1ccc(Cl)cc1

——

(-20℃)

With Ice Pack

≥ 2 years