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cjoc42
CAS No. 2171519-89-2
cjoc42( cjoc-42 | cjoc 42 )
Catalog No. M27864 CAS No. 2171519-89-2
cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 204 | In Stock |
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| 25MG | 368 | In Stock |
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| 50MG | 540 | In Stock |
|
| 100MG | 753 | In Stock |
|
| 200MG | 1014 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namecjoc42
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NoteResearch use only, not for human use.
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Brief Descriptioncjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types.
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Descriptioncjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage(In Vitro):cjoc42 (0.1, 1, and 10 μM) alone showed no dose-dependent change in cell viability. cjoc42 (0.5, 1, and 5 μM) inhibited gankyrin-induced lowering of p53 levels in cells.
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In Vitrocjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells.cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability. Western Blot Analysis Cell Line:U2OS Concentration:0.5, 1, and 5 μMIncubation Time:48 hours Result:Dose-dependent restoration of p53 levels (comparable to mock transfected cells) and inhibited gankyrin-induced lowering of p53 levels in cells.
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In Vivo——
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Synonymscjoc-42 | cjoc 42
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PathwayOthers
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TargetOther Targets
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RecptorNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number2171519-89-2
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Formula Weight415.46
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Molecular FormulaC20H21N3O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (240.70 mM)
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SMILESO=C(OC)C1=CC=C(N2N=NC(CCCOS(=O)(C3=CC=C(C)C=C3)=O)=C2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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4-Methylumbelliferyl...
4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose) is a fluorescent substrate for α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU has pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3), respectively. The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. 4-Methylumbelliferyl-α-D-Glucopyranoside can be used as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.
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ATR-101 free base
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM; induces H295R cell apoptosis.
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Histatin-8 [Hemagglu...
Histatin-8 is a part of the Histatin-3 central sequence and is known as hemagglutination-inhibiting peptide. Histatin-8 is a potent anti-fungal peptide. Histatin-8 shows antimicrobial activity against yeast strains. Histatin-8 can be used for oral thrush research.
