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cjoc42
CAS No. 2171519-89-2
cjoc42( cjoc-42 | cjoc 42 )
Catalog No. M27864 CAS No. 2171519-89-2
cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 204 | In Stock |
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| 25MG | 368 | In Stock |
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| 50MG | 540 | In Stock |
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| 100MG | 753 | In Stock |
|
| 200MG | 1014 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namecjoc42
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NoteResearch use only, not for human use.
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Brief Descriptioncjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types.
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Descriptioncjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage(In Vitro):cjoc42 (0.1, 1, and 10 μM) alone showed no dose-dependent change in cell viability. cjoc42 (0.5, 1, and 5 μM) inhibited gankyrin-induced lowering of p53 levels in cells.
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In Vitrocjoc42 (0.5, 1, and 5 μM; 48 hours) dose-dependently restores p53 levels (comparable to mock transfected cells) and inhibits gankyrin-induced lowering of p53 levels in cells.cjoc42 (0.1, 1, and 10 μM; 24 hours) alone shows no dose-dependent change in cell viability. Western Blot Analysis Cell Line:U2OS Concentration:0.5, 1, and 5 μMIncubation Time:48 hours Result:Dose-dependent restoration of p53 levels (comparable to mock transfected cells) and inhibited gankyrin-induced lowering of p53 levels in cells.
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In Vivo——
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Synonymscjoc-42 | cjoc 42
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PathwayOthers
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TargetOther Targets
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RecptorNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number2171519-89-2
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Formula Weight415.46
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Molecular FormulaC20H21N3O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (240.70 mM)
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SMILESO=C(OC)C1=CC=C(N2N=NC(CCCOS(=O)(C3=CC=C(C)C=C3)=O)=C2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CCI-006
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells. It inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response in a subset of MLL-r leukemia cells.
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Flagelin 22 TFA
Flagelin 22 TFA (Flagellin 22 TFA), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae.
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Thioflavin T
Thioflavin T is a widely used dye for visualizing and is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections.Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro.
