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Home - Products - Endocrinology/Hormones - 5-HT Receptor - AVN-101 hydrochloride?

AVN-101 hydrochloride?

CAS No. 1061354-48-0

AVN-101 hydrochloride?( AVN 101 | AVN101 )

Catalog No. M27852 CAS No. 1061354-48-0

AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 447 Get Quote
25MG 714 Get Quote
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Biological Information

  • Product Name
    AVN-101 hydrochloride?
  • Note
    Research use only, not for human use.
  • Brief Description
    AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors.
  • Description
    AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AVN 101 | AVN101
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1061354-48-0
  • Formula Weight
    340.9
  • Molecular Formula
    C21H25ClN2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nathaniel J Henning, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.
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