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AC-262536
CAS No. 870888-46-3
AC-262536( AC 262536 | AC262536 )
Catalog No. M27843 CAS No. 870888-46-3
AC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
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| 5MG | 36 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 141 | In Stock |
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| 50MG | 235 | In Stock |
|
| 100MG | 351 | In Stock |
|
| 200MG | 498 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAC-262536
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NoteResearch use only, not for human use.
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Brief DescriptionAC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor.
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DescriptionAC-262536 is a selective androgen receptor (SAR) modulator and exhibits potent agonist activity at the androgen receptor. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone.(In Vitro):AC-262536 inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP in a dose-dependent manner. The effects are significant with 100 nM, and reaches a plateau with 1 μM.(In Vivo):In male sprague-dawley rats, administration of AC-262536 (subcutaneous injection, once daily for 14 consecutive days) significantly decreased LH levels by about 40% at the 3 mg/kg dose. At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
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In VitroAC-262536 dose-dependently inhibits dihydroxytestosterone (DHT)-induced proliferation of LNCaP. The effects are significant with 100 nM AC-262536 (%inhibition 47.2±12.2), and reaches a plateau with 1 μM treatment (%inhibition 50.7±7.6). Thus, AC-262536 can act as a functional antagonist in prostate cells.
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In VivoAC-262536 (3, 10, 30 mg/kg) reverses the luteinizing hormone (LH) spike in castrated rats. Animal Model:Male Sprague-Dawley rats (200-225 g)Dosage:3, 10 and 30 mg/kg Administration:Administered subcutaneously; once daily for 14 consecutive days Result:Significantly decreased LH levels by about 40% at the 3 mg/kg dose.The ED50 was determined to be 2.8 mg/kg.At the 10 and 30 mg/kg doses, the effects of AC-262536 were significantly stronger than Testosterone Propionate (TP) : 1.91±0.32 ng/mL and 1.53±0.34 ng/mL vs. 3.12±0.69 ng/mL, respectively.
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SynonymsAC 262536 | AC262536
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PathwayEndocrinology/Hormones
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TargetAndrogen Receptor (AR)
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number870888-46-3
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Formula Weight278.355
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Molecular FormulaC18H18N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (179.63 mM)
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SMILESOC1C[C@@H]2CC[C@H](C1)N2c1ccc(C#N)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.El-Sayed, May A.; Al-Gendy, Amal. A.; Hamdan, Dalia. I.; El-Shazly, Assem M. Phytoconstituents, LC-?ESI-?MS profile, antioxidant and antimicrobial activities of Citrus x limon L. Burm. f. Cultivar variegated pink lemon. Journal of Pharmaceutical Sciences and Research (2017), 9(4), 375-391.
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