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L-822179

CAS No. 215874-86-5

L-822179( L 822179 | L822179 | L-822,179 | L 822,179 | L822,179 )

Catalog No. M27776 CAS No. 215874-86-5

L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 49 In Stock
5MG 73 In Stock
10MG 109 In Stock
25MG 186 In Stock
50MG 272 In Stock
100MG 389 In Stock
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Biological Information

  • Product Name
    L-822179
  • Note
    Research use only, not for human use.
  • Brief Description
    L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
  • Description
    L-822179 (α5IA) is a selective inverse agonist for the Α5 subtype of GABAA receptor with higher intrinsic activity at the A5 subtype than other drugs.
  • In Vitro
    Cell Viability Assay Cell Line:Primary mouse hippocampal culture Concentration:0.3 nM, 3 nM, 30 nM, 100 nM Incubation Time:24 h Result:Significantly reduced Aβ 1-42-induced cell death by 13% at a concentration of 100 nM. Significantly decreased the expression of GABAAR α5 subunit.
  • In Vivo
    ——
  • Synonyms
    L 822179 | L822179 | L-822,179 | L 822,179 | L822,179
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MIF
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    215874-86-5
  • Formula Weight
    362.353
  • Molecular Formula
    C17H14N8O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cc(no1)-c1nnc2c3ccccc3c(OCc3cn(C)nn3)nn12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zapatero MC, Pérez P, Vázquez MJ, Colmenarejo G, de Los Frailes M, Ramón F. Discovery of Novel Inhibitors of the Tautomerase Activity of Macrophage Migration Inhibitory Factor (MIF). J Biomol Screen. 2016 Jun;21(5):446-58.
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