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ABC99

CAS No. 2331255-53-7

ABC99( ABC-99 | ABC 99 )

Catalog No. M27746 CAS No. 2331255-53-7

ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 236 In Stock
2MG 158 In Stock
5MG 235 In Stock
10MG 353 In Stock
25MG 629 In Stock
50MG 923 In Stock
100MG 1283 In Stock
200MG 1730 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ABC99
  • Note
    Research use only, not for human use.
  • Brief Description
    ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.
  • Description
    ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.(In Vitro):ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner and preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.
  • In Vitro
    ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner.ABC99 preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner.Western Blot AnalysisCell Line:SW620 cells Concentration:0.1~10 μΜ Incubation Time:2 hours Result:Inhibited NOTUM in a concentration-dependent manner.
  • In Vivo
    ——
  • Synonyms
    ABC-99 | ABC 99
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Wnt/beta/catenin
  • Recptor
    TLR4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2331255-53-7
  • Formula Weight
    ——
  • Molecular Formula
    C22H21ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (54.72 mMul)
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Masaki Nakamura, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563
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