TC-A 2317 hydrochloride( —— )

Catalog No. M27721 CAS No. 1245907-03-2

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

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Biological Information

Product Name

TC-A 2317 hydrochloride
Note

Research use only, not for human use.
Brief Description

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.
Description

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.(In Vivo):In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight.
In Vitro

TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM.
In Vivo

TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight.TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats. Animal Model:HCT-116 Xenograft mice mode Dosage:P.o.; daily for 14 days Administration:30 mg/kg Result:Growth of tumor was inhibited by 59% after 14 days.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

GluR
Research Area

——
Indication

——

Chemical Information

CAS Number

1245907-03-2
Formula Weight

392.93
Molecular Formula

C19H29ClN6O
Purity

>98% (HPLC)
Solubility

——
SMILES

Cl.CC(CCCC(C)(C)O)Nc1nc(Nc2cc(C)[nH]n2)cc(C)c1[N+]#[C-]
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Hou X, et al. Superficial Chiral Etching on Achiral Metal-Organic Framework for Enantioselective Sorption. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):32264-32269.

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