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TC-A 2317 hydrochloride

CAS No. 1245907-03-2

TC-A 2317 hydrochloride( —— )

Catalog No. M27721 CAS No. 1245907-03-2

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    TC-A 2317 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.
  • Description
    TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.(In Vivo):In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight.
  • In Vitro
    TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM.
  • In Vivo
    TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight.TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats. Animal Model:HCT-116 Xenograft mice mode Dosage:P.o.; daily for 14 days Administration:30 mg/kg Result:Growth of tumor was inhibited by 59% after 14 days.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GluR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1245907-03-2
  • Formula Weight
    392.93
  • Molecular Formula
    C19H29ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CC(CCCC(C)(C)O)Nc1nc(Nc2cc(C)[nH]n2)cc(C)c1[N+]#[C-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hou X, et al. Superficial Chiral Etching on Achiral Metal-Organic Framework for Enantioselective Sorption. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):32264-32269.
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