QX-222 chloride

Research use only, not for human use.

QX222 is a sodium channel blocker.

QX222 is a sodium channel blocker.(In Vitro):Compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001), μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block twelve minutes after external application of 500 μM QX222 chloride.(In Vivo):Intravenous infusion administration of 10 mg/kg QX-222 chloride for 7 days reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.

Twelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001).

QX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.

QX 222 | Lidocaine N-Methyl Hydrochloride

Membrane Transporter/Ion Channel

Sodium Channel

c-Src

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——

5369-00-6

220.316

C13H20N2O

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (486.82 mM)

Cc1cccc(C)c1\N=C(/[O-])C[N+](C)(C)C

——

(-20℃)

With Ice Pack

≥ 2 years