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MRT-10
CAS No. 330829-30-6
MRT-10( MRT 10 )
Catalog No. M27665 CAS No. 330829-30-6
MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 59 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 59 | In Stock |
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| 10MG | 91 | In Stock |
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| 25MG | 185 | In Stock |
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| 50MG | 259 | In Stock |
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| 100MG | 363 | In Stock |
|
| 200MG | 493 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMRT-10
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NoteResearch use only, not for human use.
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Brief DescriptionMRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo).
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DescriptionMRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (an IC50 = 0.5 μM.
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In VitroMRT-10 inhibits the Smo-induced IP accumulation in a dosedependent manner (IC50=2.5 μM) in HEK293 cells.MRT-10 (10-9-10-5 M; 2 h) blocks Bodipy-cyclopamine (5 nM; 2 h) binding to cells expressing mouse Smo in a dosedependent manner with an IC50=0.5 μM.MRT-10 (10-9-10-5 M; 40 h) inhibits ShhN signaling in Shh-light2 cells in a dose-dependent manner with an IC50=0.64 μM.MRT-10 (10-9-10-5 M; 6 days) inhibits the SAG-induced (0.1 μM) alkaline phosphatase (AP) activity with an IC50=0.90 μM ) in C3H10T1/2 cells.
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In Vivo——
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SynonymsMRT 10
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number330829-30-6
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Formula Weight465.52
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Molecular FormulaC24H23N3O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (214.81 mM)
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SMILESCOc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1cccc(NC(=O)c2ccccc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Burov S, et al. Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid. J Pept Sci. 2009 Nov;15(11):760-6.
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