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ML 154
CAS No. 1345964-89-7
ML 154( NCGC84 )
Catalog No. M27660 CAS No. 1345964-89-7
ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 69 | In Stock |
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| 5MG | 107 | In Stock |
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| 10MG | 151 | In Stock |
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| 25MG | 278 | In Stock |
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| 50MG | 390 | In Stock |
|
| 100MG | 539 | In Stock |
|
| 200MG | 728 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML 154
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NoteResearch use only, not for human use.
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Brief DescriptionML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
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DescriptionML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
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In VitroWestern Blot Analysis Cell Line:CHO cells expressing NPSR Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM Incubation Time:30 min Result:Exhibited the most potent inhibition on NPS-induced ERK phosphorylation.
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In VivoAnimal Model:Male Wistar rats (300-350 g) injected with alcohol Dosage:1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) Administration:Intraperitoneal injection; once Result:Inhibited alcohol-induced central ERK phosphorylation in vivo.
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SynonymsNCGC84
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorG2019S LRRK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1345964-89-7
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Formula Weight545.48
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Molecular FormulaC29H26BrN2PS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (114.58 mM)
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SMILES[Br-].Cc1c([n+]2ccccc2n1C\C=C\c1ccccc1)P(=S)(c1ccccc1)c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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[D-Trp34]-Neuropepti...
Potent neuropeptide Y (NPY) Y5 receptor agonist (pEC50 values are 7.82, 6.28, 6.44 and > 6 at rat Y5, Y4, Y1 and Y2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y1, Y2 and Y4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo. Orally active.
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GR 231118
Potent neuropeptide Y (NPY) Y1 receptor antagonist (pA2 = 10 and 10.5 at rY1 and hY1, receptors respectively). Also a potent and selective NPY Y4 receptor agonist (pEC50 values are 6.0, 8.6 and 6.1 for rY2, hY4 and rY5 receptors respectively). Suppresses food intake in rats in vivo. Also has affinity for neuropeptide FF (NPFF) receptors in vitro (Ki = 43-73 nM).
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M617
Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
