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Adaphostin

CAS No. 241127-58-2

Adaphostin( NSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate )

Catalog No. M27602 CAS No. 241127-58-2

Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Adaphostin
  • Note
    Research use only, not for human use.
  • Brief Description
    Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.
  • Description
    Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM.(In Vitro):It also induces apoptosis in T-lymphoblastic human leukemia cell lines with IC50 ranging from 16.8 to 216.3 nM in vitro.(In Vivo):Adaphostin can damage both myeloid and lymphoid leukemia cells.
  • In Vitro
    Adaphostin down-regulates p210bcr/abl in K562 cells and inhibits granulocyte colony formation in chronic myelogenous leukemia (CML) specimens at lower concentrations without enhanced toxicity in normal progenitors.Adaphostin-induced p53 up-regulation, DNA strand breaks, and ROS production in ML-1 cells is inhibited by N-acetylcysteine (NAC).
  • In Vivo
    ——
  • Synonyms
    NSC 680410 | 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate
  • Pathway
    Angiogenesis
  • Target
    Bcr-Abl
  • Recptor
    Cyclophilin J
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    241127-58-2
  • Formula Weight
    393.483
  • Molecular Formula
    C24H27NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (127.07 mM)
  • SMILES
    Oc1ccc(O)c(CNc2ccc(cc2)C(=O)OC23CC4CC(CC(C4)C2)C3)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhao X, et al. Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity. Front Pharmacol. 2018 Feb 21;9:126.
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