DL-α-Hydroxyglutaric acid disodium salt

Research use only, not for human use.

DL-α-Hydroxyglutaric acid disodium salt is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuran carboxylic acid, which is overproduced in human neurometabolic disease D-α -hydroxyglutaric uria.

DL-α-Hydroxyglutaric acid disodium salt is an α -hydroxyacid formed from the hydrolysis of (R) -5-oxy-2-tetrahydrofuran carboxylic acid, which is overproduced in human neurometabolic disease D-α -hydroxyglutaric uria.

Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α and decreases endostatin.

——

disodium 2-hydroxypentanedioate

Others

Other Targets

S1PR1

——

——

40951-21-1

192.08

C5H6Na2O5

>98% (HPLC)

In Vitro:?H2O : 125 mg/mL (650.77 mM)

O=C([O-])C(O)CCC([O-])=O.[Na+].[Na+]

——

(-20℃)

With Ice Pack

≥ 2 years