Splenopentin diacetate

Research use only, not for human use.

Splenopentin diacetate is a synthetic immunomodulating peptide and can reproduce the biological activities of splenin and thymic hormone thymopoietin.

Splenopentin diacetate is a synthetic immunomodulating peptide and can reproduce the biological activities of splenin and thymic hormone thymopoietin.(In Vitro):Splenopentin diacetate (0.1 ng/mL-10 μg/mL) induces phenotypic differentiation of both T- and B-cell precursor cells, to increase the number of antibody-forming cells in mice after gamma irradiation.(In Vivo):Splenopentin diacetate (0.01-100 μg; i.p.) has no demonstrable effect on neuromuscular transmission of mice. Splenopentin diacetate (1 mg/kg; i.p.) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone.

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.

Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice. Animal Model:Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days Dosage:1 mg/kg Administration: I.p. three times a week for 7-90 days Result:Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.

Splenopentin Acetate | SP5 | Arg-lys-glu-val-tyr | Splenin pentapeptide (32-36) | Thymopoietin III pentapeptide (32-36) | Splenopentin Acetate |

Others

Other Targets

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105184-37-0

753.855

C33H55N9O11

>98% (HPLC)

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CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years