Naphazoline

Research use only, not for human use.

Naphazoline is a sympathomimetic compound with marked alpha adrenergic activity.

Naphazoline is a sympathomimetic compound with marked alpha adrenergic activity. Naphazoline can be used as a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.

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Naphazoline (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF. Animal Model:Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin)) Dosage:0.2 mg/mL, 10 μl per eye Administration: Intraperitoneal injection (IP), once Result:Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice.

Naphazoline | Naphcon-a | AK-Con | All Clear | Clear Eyes

Angiogenesis

Adrenergic Receptor

Antibacterial

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835-31-4

210.28

C14H14N2

>98% (HPLC)

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C(C1=NCCN1)c1cccc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years