Cart
sales@molnova.com
DM1-SMe
CAS No. 138148-68-2
DM1-SMe( —— )
Catalog No. M27400 CAS No. 138148-68-2
DM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 101 | In Stock |
|
| 5MG | 69 | In Stock |
|
| 10MG | 112 | In Stock |
|
| 25MG | 259 | In Stock |
|
| 50MG | 367 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDM1-SMe
-
NoteResearch use only, not for human use.
-
Brief DescriptionDM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
-
DescriptionDM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetMicrotubule/Tubulin
-
RecptorEstrogen Receptor/ERR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number138148-68-2
-
Formula Weight784.38
-
Molecular FormulaC36H50ClN3O10S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (127.49 mM)
-
SMILESCO[C@@H]1\C=C/C=C(C)/Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@@H](OC(=O)[C@H](C)N(C)C(=O)CCSSC)[C@]2(C)OC2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.John J. Flanagan, et al. ARV-471, an oral estrogen receptor PROTAC? protein degrader for breast cancer. American Association for Cancer Research.2019. 79 (4): P5-04-18.
molnova catalog
related products
-
DJ101
A novel potent and metabolically stable tubulin inhibitor.
-
Lexibulin
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
-
Ombrabulin
A novel combretastatin A-4 derivative and tubulin polymerization inhibitor that strongly stanches tumour blood flows and inhibits growth of tumours developing in various tissues and organ.
