UNC569

Research use only, not for human use.

Lesinurad is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body.

Lesinurad is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. Lesinurad could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.

Apoptosis Analysis Cell Line:697 and Jurkat cells Concentration:0.4 μM, 0.8 μM, 1 μM, 1.2 μM, 1.4 μM, 1.6 μM, 1.8 μM, 2 μM Incubation Time:24 hours Result:Induced apoptosis in ALL cell lines.Western Blot Analysis Cell Line:697 and Jurkat cells Concentration:1 μM Incubation Time:1.5 hours Result:Inhibited Mer activation and downstream signaling through ERK1/2 and AKT.

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Tyrosine Kinase

TAM Receptor

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1350547-65-7

396.514

C22H29FN6

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (78.81 mM)

CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1

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(-20℃)

With Ice Pack

≥ 2 years