Trepibutone

Research use only, not for human use.

Trepibutone, an acidic drug, has the capability of pH-independent release.

Trepibutone, an acidic drug, has the capability of pH-independent release.

Trepibutone (1-1000 μM) markedly relaxes the sphincter of Oddi and duodenum.

Trepibutone (1-20 mg/kg; i.v. once) dose-dependently increases bile flow.Trepibutone (10 mg/kg; i.v. 3 h after 14C-erythritol injection) stimulates canalicular bile formation without enhancement of water secretion and inhibition of bile reabsorption in the biliary ductules and ducts. Animal Model:Anesthetized beagle dogs Dosage:1-20 mg/kg Administration:Intravenous injection; 1-20 mg/kg once Result:Dose-dependently increased the bile flow of dogs and showed the peak increases of the bile flow with a dose of 10 mg/kg .Animal Model:Beagle dogs with 14C-erythritol injection Dosage:10 mg/kg Administration:Intravenous injection; 10 mg/kg; 3 h after 14C-erythritol injection Result:Increased the bile flow associated with canalicular bile flow and stimulated canalicular bile formation.

AA149 | AA 149 | AA-149 | Colibil, Supacal

Others

Other Targets

EGFR

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——

41826-92-0

310.346

C16H22O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (322.23 mM)

CCOc1ccc(C(=O)CCC(O)=O)c(OCC)c1OCC

——

(-20℃)

With Ice Pack

≥ 2 years