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Amtolmetin guacil

CAS No. 87344-06-7

Amtolmetin guacil( —— )

Catalog No. M27126 CAS No. 87344-06-7

Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 39 In Stock
5MG 29 In Stock
10MG 40 In Stock
25MG 65 In Stock
50MG 93 In Stock
100MG 138 In Stock
200MG 184 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Amtolmetin guacil
  • Note
    Research use only, not for human use.
  • Brief Description
    Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
  • Description
    Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase. Amtolmetin guacil has similar NSAID properties like tolmetin with additional analgesic, antipyretic, and gastroprotective properties.
  • In Vitro
    Amtolmetin guacil (100 μM; 0-60 min) converts to TMT (Tolmetin, HY-B1799) along with MED5 (1-methyl-5-p-methylbenzoyl-pyrrol-2-acetamido aceticacid) in rat fresh plasma and rat liver microsomal, rapidly converts to MED5 and MED5 methyl ester without yielding TMT in human fresh plasma and human liver microsomes.
  • In Vivo
    Animal Model:Male Wistar ratsDosage:50 mg/kg Administration:p.o.; single dosage Result:Pharmacokinetic Parameters of Amtolmetin guacil in male Wistar rats.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    USP30
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    87344-06-7
  • Formula Weight
    420.465
  • Molecular Formula
    C24H24N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.
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