5-Chloro-2-deoxyuridine

Research use only, not for human use.

5-Chloro-2'-deoxyuridine is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.

5-Chloro-2'-deoxyuridine is a thymine analog. It can be used to study the potential of hypochlorous acid damage to DNA and DNA precursors.(In Vitro):When 5-Chloro-2’-deoxyuridine (ClDU) is placed into the tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that a 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase .

When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase.

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5-Chlorodeoxyuridine | CldU

Others

Other Targets

TRPM4

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50-90-8

262.65

C9H11ClN2O5

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (951.84 mM)

OC[C@H]1O[C@H](C[C@@H]1O)n1cc(Cl)c(=O)[nH]c1=O

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(-20℃)

With Ice Pack

≥ 2 years