Cart
sales@molnova.com
m-PEG12-OH
CAS No. 2050595-03-2
m-PEG12-OH( Dodecaethylene Glycol Monomethyl Ether )
Catalog No. M26969 CAS No. 2050595-03-2
m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 27 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Namem-PEG12-OH
-
NoteResearch use only, not for human use.
-
Brief Descriptionm-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
-
Descriptionm-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
-
In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
-
In Vivo——
-
SynonymsDodecaethylene Glycol Monomethyl Ether
-
PathwayOthers
-
TargetOther Targets
-
RecptorDENV NS2B-NS3 protease
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2050595-03-2
-
Formula Weight560.67
-
Molecular FormulaC25H52O13
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
OD1
Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+ current at hNav1.7 channel. Increases hyperpolarization at Nav1.4 and Nav1.6 channels. Induces spontaneous pain in vivo.
-
Ainsliadimer A
Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.
-
Ipilimumab
Ipilimumab anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.
