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Talampanel
CAS No. 161832-65-1
Talampanel( GYKI-53773 | LY-300164 )
Catalog No. M26835 CAS No. 161832-65-1
Talampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 47 | In Stock |
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| 10MG | 70 | In Stock |
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| 25MG | 140 | In Stock |
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| 50MG | 230 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTalampanel
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NoteResearch use only, not for human use.
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Brief DescriptionTalampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity.
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DescriptionTalampanel is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.(In Vivo):Talampanel (p.o.; 5 mg/kg; once a day; 2 weeks) decreases motoneuronal calcium in a mouse model of ALS .
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In Vitro——
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In VivoTalampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses. Animal Model:Female mutant SOD1 Tg mice Dosage:5 mg/kg Administration:Orally administration; 5 mg/kg; once a day; 2 weeks Result:Had a significant effect in reducing the calcium level only at the age of 12 weeks.
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SynonymsGYKI-53773 | LY-300164
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PathwayApoptosis
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TargetApoptosis
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RecptorASK1
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Research Area——
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Indication——
Chemical Information
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CAS Number161832-65-1
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Formula Weight337.379
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Molecular FormulaC19H19N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (296.41 mM)
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SMILESC[C@@H]1Cc2cc3OCOc3cc2C(=NN1C(C)=O)c1ccc(N)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64.
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