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Filorexant
CAS No. 1088991-73-4
Filorexant( MK-6096 )
Catalog No. M26757 CAS No. 1088991-73-4
Filorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 112 | In Stock |
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| 25MG | 188 | In Stock |
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| 50MG | 277 | In Stock |
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| 100MG | 406 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFilorexant
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NoteResearch use only, not for human use.
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Brief DescriptionFilorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
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DescriptionFilorexant is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).(In Vitro):Filorexant occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM. Filorexant demonstrated effective binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), in radioligand binding and functional cell-based assays. It has no significant off-target activities against a panel of >170 receptors and enzymes .(In Vivo):Filorexant dose-dependently decreased locomotor activity and obviously enhanced sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
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In VitroIn radioligand binding and functional cell based assays Filorexant (MK-6096) demonstrated potent binding and antagonism of both human OX(1)R and OX(2)R (<3 nM in binding, 11 nM in FLIPR), with no significant off-target activities against a panel of >170 receptors and enzymes. Filorexant (MK-6096) occupies 90% of human OX(2)Rs expressed in transgenic rats at a plasma concentration of 142 nM.
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In VivoFilorexant (MK-6096) dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
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SynonymsMK-6096
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1088991-73-4
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Formula Weight420.488
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Molecular FormulaC24H25FN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (237.82 mM)
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SMILESC[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Maria Cristina Silva Louren?o, et al.Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents, Bioorganic & Medicinal Chemistry Letters, Volume 17, Issue 24, 2007, Pages 6895-6898.
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