(Rac)-Idroxioleic acid

Research use only, not for human use.

Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect.

Minerval is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.(In Vitro):Minerval (25-50 μM; 72 hours) causes a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis. Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner (IC50: 40 μM).(In Vivo): In nude mice infected with Jurkat cells, Minerval significantly inhibits tumour growth.

(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM.(Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis.Cell Viability Assay Cell Line:Jurkat cells Concentration:25 μM, 50 μM, 75 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Impaired Jurkat cell growth in a time- and concentration-dependent manner.Western Blot Analysis Cell Line:Jurkat cells Concentration:25 μM, 50 μM Incubation Time:72 hours Result:Induced a marked and concentration-dependent increase in the proteolytic cleavage of PARP.

(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells. Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)Dosage:600 mg/kg Administration:Oral administration; daily; for 21 days Result:Markedly and significantly inhibited tumour growth.

Minerval | 2-Hydroxyoleic acid | 2-OHOA | (Rac)-Idroxioleic acid

Apoptosis

Apoptosis

Human Endogenous Metabolite

——

——

56472-29-8

298.467

C18H34O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (335.05 mM)

CCCCCCCC\C=C/CCCCCCC(O)C(O)=O

——

(-20℃)

With Ice Pack

≥ 2 years