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Glibornuride
CAS No. 26944-48-9
Glibornuride( —— )
Catalog No. M26696 CAS No. 26944-48-9
Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 170 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 432 | In Stock |
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| 50MG | 600 | In Stock |
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| 100MG | 830 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGlibornuride
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NoteResearch use only, not for human use.
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Brief DescriptionGlibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.
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DescriptionGlibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75). Glibornuride inhibits high affinity [3H]-glibenclamide binding with the potencies expected from their K+ channel activity.(In Vivo):The diabetic group, given Glibornuride(5mg/kg), blood glucose, serum alkaline phosphatase activity, serum sialic acid, uric acid, potassium, and liver NEG levels decreased, but liver LPO, GSH, serum sodium levels, and body weight increased.
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In Vitro——
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In VivoAnimal Model:6-6.5-month-old male Swiss Albino rats, weighing 150-200 g Dosage:5 mg/kg Administration:Given by gavage, daily for 28 days Result:Administration for 28 days caused an increase in body weights in the diabetic groups. Treatment for 28 days decreased the serum uric acid levels in diabetic rats.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number26944-48-9
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Formula Weight366.48
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Molecular FormulaC18H26N2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (682.17 mM)
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SMILES[H][C@@]12CC[C@@](C)([C@@H](O)[C@H]1NC(=O)NS(=O)(=O)c1ccc(C)cc1)C2(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cheng Y, et al. 4-Methoxyestradiol-induced oxidative injuries in human lung epithelial cells. Toxicol Appl Pharmacol. 2007 May 1;220(3):271-7.
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