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Fluorofenidone

CAS No. 848353-85-5

Fluorofenidone( AKF-PD )

Catalog No. M26688 CAS No. 848353-85-5

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 49 In Stock
2MG 29 In Stock
5MG 45 In Stock
10MG 73 In Stock
25MG 150 In Stock
50MG 267 In Stock
100MG 384 In Stock
200MG 541 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Fluorofenidone
  • Note
    Research use only, not for human use.
  • Brief Description
    Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway.
  • Description
    Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an analogue of AMR69. Which displays equivalent lower toxicity, antifibrotic activity, and longer half-life.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    AKF-PD
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    848353-85-5
  • Formula Weight
    203.216
  • Molecular Formula
    C12H10FNO
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 140 mg/mL (688.94 mM)
  • SMILES
    Cc1ccc(=O)n(c1)-c1cccc(F)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.
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