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BRD7389
CAS No. 376382-11-5
BRD7389( —— )
Catalog No. M26635 CAS No. 376382-11-5
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 28 | In Stock |
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| 5MG | 44 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 138 | In Stock |
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| 100MG | 203 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBRD7389
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NoteResearch use only, not for human use.
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Brief DescriptionBRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
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DescriptionBRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.(In Vitro):BRD7389 (1 μM) almost completely blocked Carbachol (1 mM)-stimulated cell proliferation, but has little effect on the basal level of proliferation. BRD7389 (0.425, 0.85, 1.7, 3.4, 6.8 μM) induces insulin expression in mouse α-cells and induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM. BRD7389 increases β-cell-specific gene expression in primary human islet cells. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line.
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In VitroBRD7389 (0.425-6.8 μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85 μM.BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line.BRD7389 also increases β-cell-specific gene expression in primary human islet cells. BRD7389 (1 μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation. RT-PCR Cell Line:Mouse α-cell line Concentration:0.425, 0.85, 1.7, 3.4, 6.8 μM Incubation Time:3 days and 5 days Result:Up-regulated expression of Pdx1.Cell Proliferation Assay Cell Line:SNU-407 colon cancer cell Concentration:1 μM Incubation Time:Added 30 min prior to Carbachol treatment (48 h)Result:Almost completely blocked Carbachol (1 mM)-stimulated cell proliferation.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number376382-11-5
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Formula Weight366.42
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Molecular FormulaC24H18N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (56.85 mM)
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SMILESO=C1c2ccccc2-c2c(NCCc3ccccc3)c(=O)[nH]c3cccc1c23
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Spirostan-3-ol
Spirostan-3-ol is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis.
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Ammonium formate
Formic acid is the simplest carboxylic acid. Formate is an intermediate in normal metabolism. It is responsible for both metabolic acidosis and disrupting mitochondrial electron transport and energy production by inhibiting cytochrome oxidase activity the terminal electron acceptor of the electron transport chain.
