Cart
sales@molnova.com
Bevenopran
CAS No. 676500-67-7
Bevenopran( CB-5945 | ADL-5945 )
Catalog No. M26628 CAS No. 676500-67-7
Bevenopran is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
|
| 5MG | 132 | In Stock |
|
| 10MG | 198 | In Stock |
|
| 25MG | 316 | In Stock |
|
| 50MG | 421 | In Stock |
|
| 100MG | 551 | In Stock |
|
| 200MG | 728 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBevenopran
-
NoteResearch use only, not for human use.
-
Brief DescriptionBevenopran is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.
-
DescriptionBevenopran is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction.(In Vivo):Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively.
-
In Vitro——
-
In VivoBevenopran is a peripheral μ-opioid receptor antagonist. Bevenopran is currently under investigation for the treatment of opioid-induced bowel dysfunction (OBD). Bevenopran tends to increase bowel movement (BM) frequency, especially for 0.1 mg twice daily and 4 mg daily, respectively.
-
SynonymsCB-5945 | ADL-5945
-
PathwayEndocrinology/Hormones
-
TargetOpioid Receptor
-
RecptorAcidic mammalian chitinase (AMCase)| Chitotriosidase (CHIT1)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number676500-67-7
-
Formula Weight386.452
-
Molecular FormulaC20H26N4O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (323.47 mM)
-
SMILESCOc1cc(CNCCC2CCOCC2)ccc1Oc1cnc(cn1)C(N)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J Med Chem. 2020 Dec 24;63(24):15527-15540.
molnova catalog
related products
-
PF-CBP1 hydrochlorid...
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
-
Nalfurafine hydrochl...
Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5 nM, 15-fold less potent for μOR and little affinity for δOR (Ki=53 and 1,200 nM, respectively).
-
Cebranopadol
Cebranopadol (GRT-6005, GRT6005) is a potent analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist with Ki/EC50 of 0.9/13 nM (human NOP receptor), 0.7/1.2 nM (mu-opioid receptor).
