Auristatin E( —— )

Catalog No. M26615 CAS No. 160800-57-7

Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Auristatin E
Note

Research use only, not for human use.
Brief Description

Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity.
Description

Auristatin E inhibits cell division by blocking the polymerisation of tubulin. Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity. Auristatin E, an MMAE analog, is cytotoxin in Antibody-drug conjugates.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

160800-57-7
Formula Weight

732.02
Molecular Formula

C40H69N5O7
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (136.61 mM)
SMILES

[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Melo KM, et al. Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish. Environ Sci Pollut Res Int. 2015 Sep;22(18):13926-38.

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