RH01386

Research use only, not for human use.

RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses.

RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses.(In Vitro):ATP levels in βTC6 cells treated with (tunicamycin) Tm increase by RH01386.RH01386 exhibits a EC50 value of 1.894 μM. RH01386 dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells.

RH01386 (270 nM-70 μM; 72hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM.RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells.Cell Viability Assay Cell Line:βTC6 cells Concentration:270 nM-70 μM Incubation Time:72 hours Result:Inhibited ER stress-induced death of βTC6 cells in a dose-dependent manner.Apoptosis Analysis Cell Line:βTC6 cells Concentration:270 nM-70 μM Incubation Time:72 hours Result:Protected βTC6 cells from Tm-induced cell death.

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Others

Other Targets

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301177-36-6

424.4

C18H15F3N4O3S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (235.63 mM)

[O-][N+](=O)c1cc(ccc1Sc1nc(C2CCCCC2)c(C#N)c(=O)[nH]1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years