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VU 0365114

CAS No. 1208222-39-2

VU 0365114( —— )

Catalog No. M26505 CAS No. 1208222-39-2

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	56	In Stock
2MG	30	In Stock
5MG	50	In Stock
10MG	71	In Stock
25MG	132	In Stock
50MG	219	In Stock
100MG	328	In Stock
200MG	458	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

VU 0365114
Note

Research use only, not for human use.
Brief Description

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
Description

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).
In Vitro

VU 0365114 (10 μM) increases insulin secretion stimulated by ACh in human β-cells.VU 0365114 (10 μM) does not alter somatostatin secretion stimulated by ACh in human β-cells.
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

AChR
Recptor

Cleavable
Research Area

——
Indication

——

Chemical Information

CAS Number

1208222-39-2
Formula Weight

397.353
Molecular Formula

C22H14F3NO3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 77.5 mg/mL (195.04 m)
SMILES

FC(F)(F)Oc1ccc2N(Cc3ccc(cc3)-c3ccccc3)C(=O)C(=O)c2c1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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