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VBY-825
CAS No. 1310340-58-9
VBY-825( —— )
Catalog No. M26497 CAS No. 1310340-58-9
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 372 | Get Quote |
|
| 5MG | 620 | Get Quote |
|
| 10MG | 881 | Get Quote |
|
| 25MG | 1314 | Get Quote |
|
| 50MG | 1764 | Get Quote |
|
| 100MG | 2385 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameVBY-825
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NoteResearch use only, not for human use.
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Brief DescriptionVBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
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DescriptionVBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.(In Vitro):VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse.(In Vivo):10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetCysteine Protease
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1310340-58-9
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Formula Weight535.55
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Molecular FormulaC23H29F4N3O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (233.40 mM)
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SMILESCC[C@H](NC(=O)[C@H](CS(=O)(=O)CC1CC1)N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)C(=O)NC1CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kimura M, Kimura I, Muroi M, Nojima H, Diwan PV. Depolarizing neuromuscular blocking action of coryneine derived from aconite root in isolated mouse phrenic nerve-diaphragm muscles. Biol Pharm Bull. 1995 May;18(5):691-5.
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