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Pivagabine
CAS No. 69542-93-4
Pivagabine( CXB-722 )
Catalog No. M26382 CAS No. 69542-93-4
Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 25MG | 33 | In Stock |
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| 50MG | 52 | In Stock |
|
| 100MG | 86 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 212 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePivagabine
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NoteResearch use only, not for human use.
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Brief DescriptionPivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.
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DescriptionPivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.(In Vivo):Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions.
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In Vitro——
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In VivoPivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions. Animal Model:Adult male Sprague-Dawley CD rats (200-250 g)Dosage:200 mg/kg Administration:i.p.; twice a day for 4 days and 1 hour before killing on the 5th day Result:Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
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SynonymsCXB-722
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PathwayOthers
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TargetOther Targets
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RecptorGlutamate receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number69542-93-4
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Formula Weight187.239
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Molecular FormulaC9H17NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (267.04 mM)
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SMILESCC(C)(C)C(=O)NCCCC(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Andersson M, et, al. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia. Phytochemistry. 1995 Mar;38(4):835-6.
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