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Pentiapine
CAS No. 81382-51-6
Pentiapine( CGS 10746 )
Catalog No. M26364 CAS No. 81382-51-6
Pentiapine is a novel inhibitor of dopamine release.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 938 | In Stock |
|
| 5MG | 753 | In Stock |
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| 10MG | 1216 | In Stock |
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| 25MG | 1691 | In Stock |
|
| 50MG | 2213 | In Stock |
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| 100MG | 3004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePentiapine
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NoteResearch use only, not for human use.
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Brief DescriptionPentiapine is a novel inhibitor of dopamine release.
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DescriptionPentiapine is a novel inhibitor of dopamine release. (In Vivo):Pentiapine dose-dependently reduces motor activity of mice. Pentiapine dose-dependently reduces morphine-induced hyperactivity. Newman-Keuls post-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groups receiving morphine plus 2 (P<0.05), 4, 8, 16, 24 and 32 (P<0.01) mg/kg of Pentiapine. Moreover, the groups receiving morphine plus 0.5, 1 and 2 mg/kg of Pentiapine present more activity than the groups receiving morphine plus 4, 8, 16, 24 and 32 mg/kg of Pentiapine (P<0.01). 30 mg/kg dose of Pentiapine completely blocks the methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment of a cocaine CPP.
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In Vitro——
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In VivoPentiapine is a novel dopamine release inhibitor.The results show that Pentiapine dose-dependently reduces motor activity of mice. Moreover, Pentiapine dose-dependently reduces morphine-induced hyperactivity. Newman-Keuls post-hoc comparisons indicate that the group receiving morphine plus saline presents more activity than the groups receiving morphine plus 2 (P<0.05), 4, 8, 16, 24 and 32 (P<0.01) mg/kg of Pentiapine. Moreover, the groups receiving morphine plus 0.5, 1 and 2 mg/kg of Pentiapine present more activity than the groups receiving morphine plus 4, 8, 16, 24 and 32 mg/kg of Pentiapine (P<0.01). 30 mg/kg dose of Pentiapine completely blocks the methylenedioxymethamphetamine (MDMA) conditioned place preference (CPP) and also blocks the establishment of a cocaine CPP.
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SynonymsCGS 10746
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorH1 receptor| H2 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number81382-51-6
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Formula Weight299.4
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Molecular FormulaC15H17N5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (334.01 mM)
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SMILESCN1CCN(CC1)C1=Nc2ccccc2Sc2nccn12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Tripathi T, Shahid M, Khan HM, Negi MP, Siddiqui M, Khan RA. Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists. Pharmacol Rep. 2010 Sep-Oct;62(5):917-25.
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