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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - OXFBD04

OXFBD04

CAS No. 2231747-03-6

OXFBD04( —— )

Catalog No. M26352 CAS No. 2231747-03-6

OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    OXFBD04
  • Note
    Research use only, not for human use.
  • Brief Description
    OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).
  • Description
    OXFBD04 is a potent and selective inhibitor of BRD4(IC50 of 166 nM).(In Vitro):OXFBD04 (0.01-100 μM) inhibits the cell growth of cancer cell lines. In MCF7 breast cancer cells, OXFBD04 (10 μM) induces MYC suppression.(In Vivo):OXFBD04 has optimized physicochemical properties (LE = 0.43; LLE = 5.74; SFI = 5.96), and greater metabolic stability (t1/2 = 388 min, CLint = 3.57 μL/min/mg).
  • In Vitro
    OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth. OXFBD04 (10?μM; for 10, 24, or 48?hours) induces MYC suppression in MCF7 breast cancer cells. Cell Viability AssayCell Line:A498 (renal), HT-29 (colon), and MCF7 (breast) cancer cell lines Concentration:0.01, 0.1, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited cancer cell lines growth.
  • In Vivo
    OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t1/2=388?min). OXFBD04 has CLint of 3.57 μL/min/mg.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Anti-infection| Antibacterial| Antibiotic| α-glucosidase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2231747-03-6
  • Formula Weight
    296.326
  • Molecular Formula
    C17H16N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 250 mg/mL (843.68 mM)
  • SMILES
    Cc1noc(C)c1-c1cc(O)cc(c1)C(O)c1cccnc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nishida M, Murakawa T, Kamimura T, Okada N, Sakamoto H, Fukada S, Nakamoto S, Yokota Y, Miki K. In vitro and in vivo evaluation of ceftezole, a new cephalosporin derivative. Antimicrob Agents Chemother. 1976 Jul;10(1):1-13.
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